Ethanol → HCID 68456522, compound

Participants

Reaction Conditions

Reaction Steps

A 50-mL flask under argon were added 6-bromo-1-morpholinophthalazine (150 mg, 0.51 mmol), 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide (227 mg, 0.76 mmol), tetrakis(triphenylphosphine)palladium (29 mg, 0.025 mmol), ethyl alcohol (1 mL), and 1,2-dimethoxyethane (4 mL), followed by 2M potassium carbonate aqueous solution (0.77 mL, 1.53 mmol). The reaction was heated at 90° C. for 2 h. The cooled reaction was diluted with CH2Cl2 and washed with saturated aqueous NaHCO3 and brine; dried (MgSO4) and concentrated in vacuo. Trituration of the resulting crude solid with CH2Cl2 afforded a pure batch of the title compound as a white solid. Found MS (ES+): 385.1 (M+H)+.

Provenance & Evidence