Lawesson's reagent → HCID 86607618, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-cyclopropyl-4-methyl-3-(1-morpholinophthalazin-6-yl)benzamide (85 mg, 0.22 mmol) and Lawesson's reagent (97 mg, 0.24 mmol) in 1 mL THF was heated at 150° C. for 10 min in a microwave oven. Volatile solvents were removed under reduced pressure and the brown residue was purified on an ISCO column (12 g, eluted with 1-10% MeOH in ethyl acetate) to provide N-cyclopropyl-4-methyl-3-(l-morpholinophthalazin-6-yl)benzothioamide as a yellow solid. Found MS (ESI+) m/z: 405.3 (M+1).

Provenance & Evidence