反应详情

A mixture of 1-(4-chlorophenyl)pentane-1,4-dione (5.0 g., 0.024 mol, as obtained in Step-1) and 4-chloroaniline (3.33 g, 0.026 mol) in benzene (5.0 ml) was refluxed either over molecular sieves or using a Dean Stark apparatus. After three hours, benzene was removed under reduced pressure and the residue dissolved in ethyl acetate, washed with water (2×100 ml.) and brine (1×50 ml). The ethyl acetate layer was dried over anhydrous sodium sulfate, and the solvent evaporated off. The solid so obtained was washed with hexane to give 2.83 g (39.45%) of the title compound.

1. temperaturewas refluxed either over molecular sieves
2. custombenzene was removed under reduced pressure
3. dissolutionthe residue dissolved in ethyl acetate
4. washwashed with water (2×100 ml.) and brine (1×50 ml)
5. dry with materialThe ethyl acetate layer was dried over anhydrous sodium sulfate
6. customthe solvent evaporated off
7. customThe solid so obtained
8. washwas washed with hexane