Furosemide → HCID 59389122, compound

Participants

Reaction Steps

Furosemide (10) (5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid, Aldrich) (4.0 g, 12.1 mmol) was added to dioxane (100 mL), and water (50 mL) was added with stirring to give a solution. Cesium carbonate (1.97 g, 6.0 mmol) was added, and the clear solution was stirred for 1 hour. The solvent was removed by spin evaporation, and the solid was dried overnight on a vacuum pump to afford 5.31 g of cesium 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoate as a white solid.

Provenance & Evidence