N,N'-Dimethylethylenediamine → 5-chloro-N-((1-(4-(4-ethyl-2,3-dioxopiperazin-1-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide

참여 물질

역할	이름	HCID	투입량
반응물	N,N'-Dimethylethylenediamine	HCID 8070	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	1-Ethyl-2,3-piperazinedione	HCID 108812	—
반응물	5-Chloro-N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide	HCID 24986897	—
촉매	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
용매	Dimethyl Sulfoxide	HCID 679	—
용매	1,4-Dioxane	HCID 31275	—
생성물	5-chloro-N-((1-(4-(4-ethyl-2,3-dioxopiperazin-1-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide	HCID 24760231	13.6%

반응 조건

온도	110 °C

반응 단계

A mixture of 5-chloro-N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide 1-6 (70 mg, 0.16 mmol), N-ethylpiperazine-2,3-dione (45 mg, 0.32 mmol), N,N′-dimethylethylenediamine (0.020 mL, 0.19 mmol) and K2CO3 (65 mg, 0.47 mmol) in DMSO (1 mL) and dioxane (1 mL) was degassed with Ar before being charged with CuI (20 mg, 0.10 mmol). The mixture in a sealed tube was heated at 110° C. overnight. The mixture was then purified by HPLC to give the titled compound (10 mg). MS 458.1 and 460.1(M+H, Cl pattern).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07763608B2
출처 데이터셋	uspto-grants-2010_07
ORD ID	ord-90463d6f92c94e6ea467dc17263a66d0
출처 메모	uspto-grants-2010_07