2,5 Dibromotoluene → 1,4-Dibromo-2-(bromomethyl)benzene
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH3:9])[C:5]([Br:8])=[CH:6][CH:7]=1.[Br:10]Br>>[Br:1][C:2]1[CH:3]=[C:4]([C:5]([Br:8])=[CH:6][CH:7]=1)[CH2:9][Br:10]Participants
3
Procedure
In a 250 ml three-necked round-bottom flask equipped with a reflux condenser, thermometer, a pressure-equalizing dropping funnel, a magnetic stirring bar, and 74.9 g (0.30 mol) of 3,6-dibromotoluene, 15.5 ml (47.9 g, 0.30 mmol) of bromine was added dropwise under exposure to 500 W lamp for 3 hours at 190° C. The resulting mixture was cooled to room temperature. Fractional distillation gave a colorless liquid, b.p. 132-135° C./3 mm Hg. Yield, 84.3 g (85%).
Workup
- customIn a 250 ml three-necked round-bottom flask equipped with a reflux condenser
- distillationFractional distillation
- customgave a colorless liquid, b.p. 132-135° C./3 mm Hg
- customYield
Sources & evidence
- ORD record
- ord-f660081da2af4da1935cdbdf2041cd7e
- Source dataset
- uspto-grants-2010_07
- Patent number
- US07763562B2
Reaction notes
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