HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Carbonate → HCID 68637486, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Carbonate | HCID 7766 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Benzoic acid, 2,3,5-trifluoro-, ethyl ester | HCID 53419349 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 68637486 | HCID 68637486 | 82.9% |
Reaction Steps
Ethyl 2-(2,3,5-trifluorophenyl)-acetate (29 g) was slowly added to a mixture of diethylcarbonate (63 g) and sodium hydride (9.5 g) in toluene (350 ml). After being refluxed for 3 hours, the reaction mixture was cooled, treated with ice-water and washed with water. The organic layer was separated, dried and filtered. The filtrate was concentrated in vacuo to yield 32 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763622B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-b4adab8be14a42df801d63a3755c957b |
| Source note | uspto-grants-2010_07 |