反应详情

The compound of Example 113 (2.97 g) was dissolved in methanol (50.0 mL). To this solution, sodium methoxide (1.42 g) was added and the mixture was stirred for 2 hours under reflux. After cooling, the solvent was evaporated. Water was added to the resulting residue and the mixture was extracted with ethyl acetate. The organic layer was washed sequentially with water and saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated and the residue was suspended in diisopropyl ether. The solid product was collected by filtration to afford the title compound as a yellowish green powder (1.93 g).

1. temperatureunder reflux
2. temperatureAfter cooling
3. customthe solvent was evaporated
4. additionWater was added to the resulting residue
5. extractionthe mixture was extracted with ethyl acetate
6. washThe organic layer was washed sequentially with water and saturated brine
7. dry with materialdried over anhydrous sodium sulfate
8. customThe solvent was evaporated
9. filtrationThe solid product was collected by filtration