Hydrochloric Acid → HCID 59389365, compound

Participants

Reaction Steps

A 1 mol/L aqueous sodium hydroxide solution (12 mL) was added to a solution of the compound of Example 184 (460 mg) in methanol (30 mL). The mixture was stirred at room temperature for 2 days. Subsequently, diluted hydrochloric acid was added to make the mixture acidic. Methanol was evaporated and the residue was extracted with ethyl acetate (×2). The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. Evaporation of the solvent and subsequent purification of the residue by silica gel column chromatography (hexane:ethyl acetate=2:3) afforded the title compound as a pale green powder (295 mg).

Provenance & Evidence