Potassium Hydroxide → HCID 59389339, compound

Participants

Reaction Conditions

Reaction Steps

The compound of Example 182 (as a mixture) was dissolved in 47% hydrobromic acid (20 mL) and the mixture was stirred at 130° C. for 1 hour. After cooling, a 20% aqueous potassium hydroxide solution was added to make the mixture basic. The mixture was then washed with diethyl ether and diluted hydrochloric acid was added to make the aqueous layer acidic. The mixture was extracted with ethyl acetate and the organic layer was washed with water and saturated brine and dried over anhydrous sodium sulfate. Evaporation of the solvent afforded a pale yellow powder. The crude product was used in the subsequent reaction without further purification.

Provenance & Evidence