Hydrazine, acetate (1:1) → HCID 11955202, compound

HRID 2357920Notes

Reaction equation

HRID 2357920 reaction equation
[CH3:1][O:2][C:3]1[N:8]2[N:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=[C:7]2[C:6]([CH2:16][CH2:17][C:18](=O)[C:19]([OH:21])=O)=[CH:5][CH:4]=1.C(O)(=O)C.[NH2:27][NH2:28]>C(O)C>[CH3:1][O:2][C:3]1[N:8]2[N:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=[C:7]2[C:6]([C:16]2[CH2:17][CH2:18][C:19](=[O:21])[NH:27][N:28]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 165591Hydrazine, acetate (1:1)HCID 68457804HCID 68457804, compound

Product 1

HCID 11955202HCID 11955202, compoundYield 20.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound of Example 207 (616 mg, crude) was dissolved in ethanol (15.0 mL). To this solution, hydrazine monoacetate (428 mg) was added and the mixture was stirred for 8 hours under reflux. Subsequently, the solvent was evaporated and the residue was purified by amino-silica gel column chromatography (ethyl acetate) to afford the title compound as a yellow powder (123 mg).

Workup

  1. temperatureunder reflux
  2. customSubsequently, the solvent was evaporated
  3. customthe residue was purified by amino-silica gel column chromatography (ethyl acetate)

Sources & evidence

ORD record
ord-6061309975eb43bbb71f9a649c48a5df
Source dataset
uspto-grants-2010_07
Patent number
US07763617B2

Reaction notes

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