Acetic Acid → HCID 53248667, compound

HRID 2357934Notes

Reaction equation

HRID 2357934 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[C:9]3[N:10]([N:16]=[C:17]([CH:19]([CH3:21])[CH3:20])[CH:18]=3)[C:11]([O:14][CH3:15])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.C(O)(=[O:24])C>>[CH3:15][O:14][C:11]1[N:10]2[N:16]=[C:17]([CH:19]([CH3:21])[CH3:20])[CH:18]=[C:9]2[C:8]([C:5]2[CH:4]=[CH:3][C:2](=[O:24])[NH:7][N:6]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 54584479HCID 54584479, compound

Product 1

HCID 53248667HCID 53248667, compound

Conditions

Temperature
90 °C

Procedure

The compound of Example 268 (50 mg) was dissolved in acetic acid (2 mL) and the solution was stirred at 90° C. for 3 hours. Subsequently, the solvent was concentrated and the residue was purified by silica gel column chromatography (methanol:ethyl acetate 1:9) to afford the title compound as a pale yellow powder (26 mg).

Workup

  1. concentrationSubsequently, the solvent was concentrated
  2. customthe residue was purified by silica gel column chromatography (methanol:ethyl acetate 1:9)

Sources & evidence

ORD record
ord-46fcf51da4d94b25b2cf06b0f9d50fec
Source dataset
uspto-grants-2010_07
Patent number
US07763617B2

Reaction notes

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