Hydrochloric Acid → HCID 11955204, compound

Participants

Reaction Steps

The compound of Example 209 (79.8 mg) and sodium m-nitrosulfonate (57.6 mg) were suspended in a 0.5 mol/L aqueous sodium hydroxide solution (5.00 mL). The suspension was refluxed for 8 hours. Subsequently, diluted hydrochloric acid was added to make the mixture acidic and the mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. Evaporation of the solvent and subsequent purification of the residue by amino-silica gel column chromatography (ethyl acetate) afforded the title compound as a yellow powder (23.1 mg).

Provenance & Evidence