Trimethylamine → HCID 86741298, compound

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Reaction Steps

4.1 g. 4-(2,3-Epoxypropoxy)-indolin-2-one (Example 6) are dissolved in 40 ml. dimethyl sulphoxide, mixed with 2.0 g. pyrazole-5-aldehyde and 2.8 ml. trimethylamine and stirred for 2 days at ambient temperature. The reaction mixture is mixed with 150 ml. water and extracted with ethyl acetate. After drying with anhydrous sodium sulphate and evaporating, there crystallise out 3.9 g. 4-(2,3-epoxypropoxy)-3-(pyrazol-5-yl)-methyleneindolin-2-one; m.p. 229° C.; yield 68% of theory.

Provenance & Evidence