Hydrochloric Acid → HCID 59389320, compound

Participants

Reaction Steps

An aqueous solution (1 mL) of sodium hydroxide (41.9 mg) was added to an aqueous solution (3 mL) of silver nitrate (89.0 mg). To this mixture, the compound of Example 237 (60.0 mg) was added and the resulting mixture was stirred at room temperature for 1 hour. Subsequently, 5% hydrochloric acid was added to adjust the pH to 3. The insoluble material was separated by filtration and washed with a 7:1 mixture of chloroform and methanol. The filtrate and wash were combined. Sodium chloride was then added and the mixture was extracted with a 7:1 mixture of chloroform and methanol. The extract was dried over an hydrous magnesium sulfate and the solvent was evaporated. Methanol was added to the residue and the insoluble material was removed by filtration. The solvent of the filtrate was evaporated to afford the title compound as a pale yellow powder (46.3 mg).

Provenance & Evidence