Potassium Hydroxide → HCID 59389290, compound

Participants

Reaction Conditions

Reaction Steps

A 4 mol/L aqueous potassium hydroxide solution (7.0 mL) was added to a solution of the compound of Example 352 (3.33 g) in methanol (50 mL). The mixture was refluxed for 2 hours. Subsequently, the mixture was concentrated and made acidic. The resultant crystals were collected by filtration. To this product, 1,2-dichlorobenzene (50 mL) was added and the mixture was stirred at 150° C. overnight. Evaporation of the solvent and subsequent purification by silica gel column chromatography (hexane:ethylacetate=3:1→1:1) afforded the title compound as a colorless powder (1.28 g).

Provenance & Evidence