Water → HCID 59389392, compound

Participants

Reaction Steps

Triethylamine (6.08 mL) was added to a solution of the compound of Example 355 (1.41 g) in dimethylsulfoxide (30 mL). While the solution was stirred at room temperature, sulfur trioxide-pyridine complex (3.46 g) was added and the mixture was stirred at room temperature for 30 min. Water (150 mL) was then added and the resulting crystals were collected by filtration. The crystals were dissolved in ethyl acetate and the solution was dried over anhydrous sodium sulfate. Purification by amino-silica gel column chromatography (ethyl acetate) afforded the title compound as a colorless powder (1.16 g).

Provenance & Evidence