HCID 178418600, compound → HCID 178512929, compound

HRID 235798Notes

Reaction equation

HRID 235798 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].[CH:13]1[CH:14]=[CH:15][C:16]([C:19]2([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[NH:24][C:23]([O-:25])=[N:22][C:20]2=[O:21])=[CH:17][CH:18]=1.[Na+:32]>O.[OH-].[Na+]>[CH:29]1[CH:28]=[CH:27][C:26]([C:19]2([C:16]3[CH:15]=[CH:14][CH:13]=[CH:18][CH:17]=3)[NH:24][C:23]([O-:25])=[N:22][C:20]2=[O:21])=[CH:31][CH:30]=1.[Na+:32].[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

Participants

5

Reactant 2

HCID 178418600HCID 178418600, compoundHCID 178518528HCID 178518528, compound

Product 1

HCID 178512929HCID 178512929, compound

Reagents, catalysts & solvents 2

HCID 14798Sodium HydroxideCatalystHCID 962WaterSolvent

Procedure

Arginine (1.6 g, 4.6 mmol) was dissolved in 20 ml water and added to 1.25 g (4.6 mmol) phenytoin sodium with stirring. One drop of 10 N sodium hydroxide solution was added to complete the dissolution of the solid. After about 30 min. stirring, the pH of the solution stabilized at 11.4-11.6.

Workup

  1. dissolutionthe dissolution of the solid
  2. stirringAfter about 30 min. stirring

Sources & evidence

ORD record
ord-aed52c31015a449c876ee2d44d3e8050
Source dataset
uspto-grants-1987_02
Patent number
US04642316

Reaction notes

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