Sodium Hydroxide → HCID 16049114, compound

Participants

Reaction Steps

To a stirred solution of 300 mg (0.72 mmol) of ethyl 2-(3-(2,6-dimethylphenylamino)-6-(phenylamino)-1H-indazol-1-yl)acetate 64 (Example 29) in MeOH (10 mL) was added 1 N NaOH solution (4 mL, 4 mmol). The mixture was stirred at room temperature for 8 hours before being concentrated under reduced pressure. The residue was extracted with DCM (5 mL×2) and neutralized with 3 N HCl solution to pH 2. The resulting yellow solid was filtered, washed with water and dried to give the title compound. 1H-NMR (DMSO-d6) δ 2.20 (s, 6H), 4.74 (s, 2H), 6.96 (t, J=7.2 Hz, 1H), 7.05-7.09 (m, 3H), 7.28 (t, J=7.7 Hz, 2H), 7.79 (d, J=7.9 Hz, 2H), 8.22 (s, 1H), 8.53 (s, 1H), 9.77 (s, 1H). Mass Spectrum (ESI) m/e=389 (M+1).

Provenance & Evidence