Ethanolamine → HCID 178511454, compound

HRID 235800Notes

Reaction equation

HRID 235800 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].[CH:5]1[CH:6]=[CH:7][C:8]([C:11]2([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[NH:16][C:15]([O-:17])=[N:14][C:12]2=[O:13])=[CH:9][CH:10]=1.[Na+:24]>O.[OH-].[Na+]>[CH:21]1[CH:20]=[CH:19][C:18]([C:11]2([C:8]3[CH:7]=[CH:6][CH:5]=[CH:10][CH:9]=3)[NH:16][C:15]([O-:17])=[N:14][C:12]2=[O:13])=[CH:23][CH:22]=1.[Na+:24].[CH2:1]([CH2:3][NH2:4])[OH:2]

Participants

5

Reactant 2

HCID 700EthanolamineHCID 178518528HCID 178518528, compound

Product 1

HCID 178511454HCID 178511454, compound

Reagents, catalysts & solvents 2

HCID 14798Sodium HydroxideCatalystHCID 962WaterSolvent

Procedure

Monoethanolamine (0.3 g, 4.9 mmol) in 10 ml water was added to 1.25 g (4.6 mmol) phenytoin sodium, and the cloudy suspension was diluted to 25 ml. To obtain a clear solution, 2-3 drops 10 N sodium hydroxide was added and the solution stirred giving a pH of 11.6-11.8.

Workup

  1. additionthe cloudy suspension was diluted to 25 ml
  2. additionwas added
  3. customgiving a pH of 11.6-11.8

Sources & evidence

ORD record
ord-648ee98f1641465e874b916f50af0b43
Source dataset
uspto-grants-1987_02
Patent number
US04642316

Reaction notes

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