Sodium Hydroxide → HCID 59262332, compound

HRID 2358010Notes

Reaction equation

HRID 2358010 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][S:12](=[O:15])(=[O:14])[N:11]=[C:10](SC)[NH:9]2)=[CH:4][CH:3]=1.[OH-:18].[Na+]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][S:12](=[O:15])(=[O:14])[NH:11][C:10](=[O:18])[NH:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178503624HCID 178503624, compound

Product 1

HCID 59262332HCID 59262332, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Using a method similar to that described by K. Hasegawa and S. Hirooka (Bull. Chem. Soc. Jap., 1972, 45, 1893), 5-(4-chlorophenyl)-3-methylsulfanyl-5,6-dihydro-4H-[1,2,4]thiadiazine 1,1-dioxide DE2 in acetone is treated with 1N NaOH and the mixture is refluxed for 2 h. The acetone is evaporated and the mixture is acidified with conc. HCl to afford the title compound DE3.

Workup

  1. temperaturethe mixture is refluxed for 2 h
  2. customThe acetone is evaporated

Sources & evidence

ORD record
ord-59d23d4565094442b8a5031f904e1309
Source dataset
uspto-grants-2010_07
Patent number
US07763609B2

Reaction notes

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