HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(6-(trifluoromethyl)pyridin-3-yl)propanoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Methyl 3-(6-(trifluoromethyl)pyridin-3-yl)propanoate | HCID 53406715 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(6-(trifluoromethyl)pyridin-3-yl)propanoic Acid | HCID 2783390 | — |
Reaction Steps
Lithium hydroxide monohydrate (330 mg) is added in one portion to a solution of 3-(6-trifluoromethyl-pyridin-3-yl)-propionic acid methyl ester (610 mg) in a mixture of THF (15 mL) and water (5 mL). The mixture is stirred for 20 h at RT. DCM and aqueous HCl (1.0 M) are added, the layers are separated and the aqueous layer is extracted twice with DCM. The combined organic extracts are dried over MgSO4 and concentrated in vacuo to give the desired propionic acid as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763638B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-951c9cd9b2d2478792fc3bc66a28d8fd |
| Source note | uspto-grants-2010_07 |