Diisopropylethylamine → HCID 11591606, compound

Participants

Reaction Steps

A mixture of {6,7-dimethoxy-1-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-3,4-dihydro-1H-isoquinolin-2-yl}-phenyl-acetic acid (0.20 mmol), methylamine hydrochloride (0.20 mmol), PyBOP (0.20 mmol) and DIPEA (0.46 mmol) in DMF (1.0 mL) is stirred at RT for 20 h. Water and EA are added, the layers are separated and the aqueous layer is extracted with EA. The combined organic extracts are dried over MgSO4 and concentrated in vacuo. The residue is purified by flash chromatography (EA) to give the desired product as a viscous oil.

Provenance & Evidence