Triethylamine → HCID 178502904, compound

Participants

Reaction Conditions

Reaction Steps

169.2 mg (20 mMol) O-methylhydroxylamine hydrochloride and 2.0 g (8.3 mMol) S-methyl-N-cyano-N′-(6-chloropyrid-3-yl)isothiourea are added to 50 ml ethanol and treated with 1.27 ml (9.1 mMol) triethylamine and 50.0 ml water. The reaction mixture is then stirred for ca. 18 hours at 60° C. under a protective gas (argon). At the end of the reaction the ethanol is distilled off under reduced pressure and the aqueous residue is extracted three times with chloroform. After drying the organic phase is evaporated to dryness under reduced pressure and the residue is purified by preparative HPLC. 13.5 mg (0.7%) N-methoxyamino-N′-(6-chloropyrid-3-yl)cyanoguanidine are obtained.

Provenance & Evidence