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Hydrochloric Acid → 1-[2-Fluoro-3-(trifluoromethyl)phenyl]-4-propylpiperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Iodopropane | HCID 33643 | — |
| 反応物 | 1-(2-Fluoro-3-(trifluoromethyl)phenyl)piperazine | HCID 57448041 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1-[2-Fluoro-3-(trifluoromethyl)phenyl]-4-propylpiperazine | HCID 11601723 | — |
反応手順
Preparation according to Example 1: 1-[2-fluoro-3-(trifluoro-methyl)phenyl]piperazine (0.97 g, 3.9 mmol), acetonitrile (50 ml), potassium carbonate (0.81 g, 5.86 mmol) and 1-iodopropane (0.457 ml, 4.6 mmol). Yield: 0.57 g (50%). The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 180-181° C. MS m/z (relative intensity, 70 eV) 290 (M+, 22), 262 (13), 261 (bp), 218 (18), 190 (22).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07763639B2 |
| 出典データセット | uspto-grants-2010_07 |
| ORD ID | ord-90c46f5ff4a945ffbb0d5f817b3a7aa3 |
| 出典メモ | uspto-grants-2010_07 |