HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-(2-methoxyethyl)-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromoethyl methyl ether | HCID 80972 | — |
| Reactant | 4-[2-Fluoro-3-(methylsulfonyl)phenyl]piperidine | HCID 57448038 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-(2-methoxyethyl)-piperidine | HCID 11529764 | — |
Reaction Steps
Preparation according to Example 1: 4-[2-fluoro-3-(methylsulfonyl)-phenyl]-piperidine (0.53 g, 1.64 mmol), acetonitrile (20 ml), potassium carbonate (0.45 g, 3.2 mmol), 1-bromo-2-methoxyethane (0.167 ml, 1.72 mmol). MS m/z (relative intensity, 70 eV) 315 (M+, 1), 271 (14), 270 (bp), 147 (10) 133 (9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763639B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-00e1d975f95e4a289a8b01ab029e2f35 |
| Source note | uspto-grants-2010_07 |