Fumaric Acid → HCID 67533753, compound

HRID 2358065Notes

Reaction equation

HRID 2358065 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]=[C:6]([C:9]2[C:10]([F:21])=[C:11]([S:15]([N:18]([CH3:20])[CH3:19])(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=2)[CH2:5][CH2:4]1)[CH3:2].C(O)(=O)/C=C/C(O)=O>[Pt]=O.CO>[CH2:1]([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[C:10]([F:21])=[C:11]([S:15]([N:18]([CH3:20])[CH3:19])(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=2)[CH2:5][CH2:4]1)[CH3:2]

Participants

5

Reactant 2

HCID 444972Fumaric AcidHCID 67533539HCID 67533539, compound

Product 1

HCID 67533753HCID 67533753, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

Preparation according to Example 3: 3-(1-ethyl-1,2,3,6-tetrahydropyridin-4-yl)-2-fluoro-N,N-dimethylbenzenesulfonamide (0.27 g, 0.86 mmol), methanol (10 ml), platinum oxide (0.05 g). Yield: 0.16 g (59%). The amine was converted to fumaric acid salt and recrystallized from ethanol/diisopropyl ether: M.p. 151-152° C. MS m/z (relative intensity, 70 eV) 314 (M+, 18), 313 (11), 300 (17), 299 (bp) 191 (11).

Workup

  1. customPreparation
  2. customrecrystallized from ethanol/diisopropyl ether

Sources & evidence

ORD record
ord-451216674bbc48d1880b6716cfe72bf7
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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