Benzyl mercaptan → HCID 20217508, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of sodium ethylate prepared from sodium (2.3 g) and ethanol (160 cc), benzyl mercaptan (13.6 g) is added and the mixture is stirred for 1 hour at a temperature in the region of 20° C. 2-Amino-7chloro-1,8-naphthyridine (18 g) is then added and the mixture is heated for 6 hours at 60° C. The suspension produced is poured into water (500 cc) and extracted with methylene chloride (3×250 cc). After being washed with water and dried, the organic solution is concentrated to dryness under reduced pressure (4 kPa) to give 2amino-7-benzylthio-1,8-naphthyridine (15.4 g), m.p. 167° C. EXAMPLE 11

Provenance & Evidence