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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2358141Generated: October 25, 2026

Methyl 4-[2-fluoro-3-(methylsulfonyl)phenyl]piperazine-1-carboxylate → 1-[2-Fluoro-3-(methylsulfonyl)phenyl]piperazine

https://huagongshe.com/reaction/2358141

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-[2-fluoro-3-(methylsulfonyl)phenyl]piperazine-1-carboxylateHCID 57448075—
SolventHydrochloric AcidHCID 313—
SolventEthanolHCID 702—
Product1-[2-Fluoro-3-(methylsulfonyl)phenyl]piperazineHCID 57448050—

Reaction Steps

Preparation according to preparation 29: methyl 4-[2-fluoro-3-(methylsulfonyl)phenyl]piperazine-1-carboxylate (1.0 g, 3.16 mmol) in ethanol (8 ml), hydrochloric acid (6 M, 20 ml). Yield: 0.34 g. MS m/z (rel. intensity, 70 eV) 258 (M+, 17), 215 (13), 216 (bp), 209 (6), 137 (9).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07763639B2
Source datasetuspto-grants-2010_07
ORD IDord-a6abfe621f134602b5e87e19e7a5fb1d
Source noteuspto-grants-2010_07