HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 1-Ethyl-4-[2-fluoro-3-(methylsulfonyl)phenyl]-1,2,3,6-tetrahydropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ethylacetate methanol | HCID 21584119 | — |
| Reactant | 1-Ethyl-4-(2-fluoro-3-(methylthio)phenyl)-1,2,3,6-tetrahydropyridine | HCID 58988417 | — |
| Catalyst | Sodium tungstate | HCID 26052 | — |
| Product | 1-Ethyl-4-[2-fluoro-3-(methylsulfonyl)phenyl]-1,2,3,6-tetrahydropyridine | HCID 16655345 | — |
Reaction Steps
Preparation according to preparation 64: 1-ethyl-4-[2-fluoro-3-(methylthio)phenyl]-1,2,3,6-tetrahydropyridine (22.5 g, 89.6 mmol), sulfuric acid (1 M, 180 ml), sodium tungstate (0.296 g, 0.89 mmol), hydrogen peroxide (30%, 22.9 ml, 224 mmol). Flash column chromatography (ethyl acetate/methanol, 1:1) gave the title compound (17.2 g). MS m/z (rel. intensity, 70 eV) 283 (M+, 63), 268 (bp), 146 (51), 110 (87), 56 (59).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763639B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-f96df6e4d0f84c4fae68993aed822df6 |
| Source note | uspto-grants-2010_07 |