1,2-Dimethyl-1H-benzimidazol-5-amine → HCID 15984149, compound

HRID 2358159Notes

Reaction equation

HRID 2358159 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][N:9]2[C:13]3=[N:14][CH:15]=[CH:16][CH:17]=[C:12]3[CH:11]=[C:10]2[C:18]([O:20]CC)=O)[CH:5]=[CH:6][CH:7]=1.[NH2:23][C:24]1[CH:34]=[CH:33][C:27]2[N:28]([CH3:32])[C:29]([CH3:31])=[N:30][C:26]=2[CH:25]=1>>[CH3:32][N:28]1[C:27]2[CH:33]=[CH:34][C:24]([NH:23][C:18]([C:10]3[N:9]([CH2:8][C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=4)[C:13]4=[N:14][CH:15]=[CH:16][CH:17]=[C:12]4[CH:11]=3)=[O:20])=[CH:25][C:26]=2[N:30]=[C:29]1[CH3:31]

Participants

3

Reactant 2

HCID 9653551,2-Dimethyl-1H-benzimidazol-5-amineHCID 44608255HCID 44608255, compound

Product 1

HCID 15984149HCID 15984149, compoundYield 86.1%

Procedure

The process is performed according to the method described in Example 11, starting with 0.4 g (1.34 mmol) of ethyl 1-[(3-fluorophenyl)methyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (Example 5.3) and 0.25 g (1.61 mmol) of 5-amino-1,2-dimethylbenzimidazole. 0.477 g of expected compound is isolated.

Sources & evidence

ORD record
ord-7fa4180154644ce48d0eb4b563ace756
Source dataset
uspto-grants-2010_07
Patent number
US07763636B2

Reaction notes

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