5-Benzothiazolamine, 2-methyl- → HCID 15984951, compound

HRID 2358161Notes

Reaction equation

HRID 2358161 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[CH:10]=[C:9]([C:11]([O:13]CC)=O)[N:8]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=3)[C:5]2=[CH:6][N:7]=1.[NH2:24][C:25]1[CH:26]=[CH:27][C:28]2[S:32][C:31]([CH3:33])=[N:30][C:29]=2[CH:34]=1>>[CH3:33][C:31]1[S:32][C:28]2[CH:27]=[CH:26][C:25]([NH:24][C:11]([C:9]3[N:8]([CH2:16][C:17]4[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=4)[C:5]4=[CH:6][N:7]=[C:2]([F:1])[CH:3]=[C:4]4[CH:10]=3)=[O:13])=[CH:34][C:29]=2[N:30]=1

Participants

3

Reactant 2

HCID 362295-Benzothiazolamine, 2-methyl-HCID 67546418HCID 67546418, compound

Product 1

HCID 15984951HCID 15984951, compoundYield 87.2%

Procedure

The process is performed according to the method described in step 2.4 of Example 2, starting with 0.3 g (0.95 mmol) of ethyl 5-fluoro-1-[(3-fluorophenyl)methyl]-1H-pyrrolo[2,3-c]pyridine-2-carboxylate (Example 2.3) and 0.189 mg (1.14 mmol) of 5-amino-2-methylbenzothiazole. 0.36 g of expected compound is isolated.

Sources & evidence

ORD record
ord-77e5aaf57a204c0784e073748173223a
Source dataset
uspto-grants-2010_07
Patent number
US07763636B2

Reaction notes

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