Hydrochloric Acid → Methyl 3-(chlorocarbonyl)-5-nitrobenzoate

Participants

Reaction Steps

A suspension of 5-nitro-isophtalic acid mono methyl ester (22.52 g, 100.0 mmol) in thionyl chloride (50 ml) was heated to reflux for 6 hours (until the production of SO2 and HCl-gas ceased). The excess of thionyl chloride was removed under reduced pressure, the residue was dissolved in DCM and the product was precipitated by addition of hexane to give a white solid. Yield: 24.10 g (99%).

Provenance & Evidence