Toluene → HCID 58880275, compound

Participants

Reaction Steps

3-(3-Fluoro-4-sulfamoyloxy-benzenesulfonylamino)-5-[1,2,4]triazol-1-ylmethyl-benzoic acid methyl ester (CAB04128, STX1528): Sulphamoyl chloride solution in toluene (3 ml, 0.7 M, 2.1 mmol) was concentrated under reduced pressure. The residue was dissolved In DMA (5 ml) at 0° C. and CAB04122 (120 mg, 0.295 mmol) was added to the solution. Stirring was continued for 18 hours, EtOAc (50 ml) and water 30 ml were added, the organic layer was separated, washed with water (3×30 ml) and brine (20 ml), dried (Na2SO4) and concentrated under reduced pressure. The residue was purified by flash chromatography on silica (chloroform/acetone 1:1) to give the title compound as a light yellow solid. Yield 86 mg (60%).

Provenance & Evidence