Ammonia → 1-(Aminomethyl)-4-propylpyrrolidin-2-one

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Reaction Steps

A solution of 1-chloromethyl-4-propyl-pyrrolidin-2-one (41.34 g, 0.235 mol) in toluene (350 ml) was added dropwise at −78° C. to liquid ammonia (300 ml). At the end of the addition, the temperature was raised slowly to room temperature and ammonia of the crude mixture was allowed to distilled at room temperature overnight. Filtration of the crude solution and subsequent evaporation lead to 55 g of the crude product a27 which was used without further purification.

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