HCID 11197984, compound → HCID 58911277, compound

Participants

Reaction Steps

In a 250 ml parr apparatus, Pd/C (0.1 g, 10% w/w) is added onto a solution of the enantiomerically pure (+)-1-{[2-oxo-4-(3,4,5-trifluorophenyl)pyrrolidin-1-yl]methyl}-1H-imidazole-4-carbonitrile 79 (0.2 g, 0.624 mmol) in NH3/MeOH (3 M, 30 ml) and the suspension is stirred under an hydrogen pressure (50 psi) for 6 h. The reaction mixture is concentrated in vacuo, dissolved in AcOEt, dried over MgSO4, filtered and concentrated in vacuo to afford 0.14 g of crude 1-(5-aminomethyl-imidazol-1-ylmethyl)-4-(3,4,5-trifluoro-phenyl)-pyrrolidin-2-one a34 which is used as such in the next step.

Provenance & Evidence