反应详情

The intermediate from Example 1 Step D (2.9 g, 6.55 mmol) was dissolved in 200 mL of a 60:40 mixture of 1,2-dichloroethane-ethanol. The mixture was irradiated under a high intensity light for 3 days. The volatiles were removed in vacuo and the crude material was triturated with DCM and filtered. The product was triturated twice more with EtOAc and filtered. 1 NMR 400 MHz, DMSO-d6: δ14.12 (br, 1H), 11.82 (m, 1H), 10.55(m, 1H), 7.40˜7.90(m, 7H): [M+1]+ 442.

1. customThe mixture was irradiated under a high intensity light for 3 days
2. customThe volatiles were removed in vacuo
3. customthe crude material was triturated with DCM
4. filtrationfiltered
5. customThe product was triturated twice more with EtOAc
6. filtrationfiltered