Acetic Acid → HCID 22555951, compound

Participants

Reaction Steps

A solution of 2 (3.11 g, 9.39 mmol) in a mixture of 6N hydrochloric acid (150 mL) and dioxane (150 mL) was heated at reflux under Ar for 18 h. Acetic acid (50 mL) was added and heating was continued for an additional 4 h. The organic solvents were removed in vacuo and the remaining aqueous was extracted with ethyl acetate (3×), washed with brine and dried with sodium sulfate (anh.). Filtration followed by removal of the solvent in vacuo gave 3 as a white solid (1.32 g, 55%)

Provenance & Evidence