HOAt → HCID 58828525, compound

Participants

Reaction Steps

A solution of 3 (1.00 g, 3.91 mmol), 4 (740 mg, 4.30 mmol), 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (826 mg, 4.30 mmol), 1-hydroxy-7-azabenzotriazole (585 mg, 4.30 mmol) and NN-diisopropylethylamine (0.748 mL, 4.30 mmol) in N,N-dimethylformamide (5 mL) was stirred at room temperature for 2 days. The contents of the reaction flask were poured into water and sat. sodium bicarbonate then extracted with ethyl acetate (3×). The combined organic extracts were washed with 5% potassium bisulfate and brine. The organic layer was dried with sodium sulfate (anh.), filtered and concentrated in vacuo. Flash column chromatography (hexane/ethyl acetate 70:30) gave 5 (1.05 g, 68%)

Provenance & Evidence