Potassium Carbonate → HCID 11429549, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the phenol 62 (64 mg, 0.2 mmol), K2CO3 (83 mg, 0.6 mmol) and trifluoroethyl triflate (70 mg, 0.3 mmol) in DMF (3 mL) was heated at 50° C. for 30 min. The reaction was cooled, poured into saturated aqueous NaHCO3 and extracted with EtOAc. The combined organic extracts were washed once with 1N HCl and brine, dried with Na2SO4, filtered and concentrated in vacuo. Trituration of the residue with EtOAc/Hexane provided desired product 63.

Provenance & Evidence