反应详情

温度

4 °C

The procedure is similar to that described in Example 37, but starting with 2-amino-7-chloro-1,8-naphthyridine (18 g), 3-fluorophenol (44.8 g) and potassium hydroxide pellets (13.2 g; 85% purity). After treatment with caustic soda and washing, the product produced (23.5 g; m.p. 161° C.) is dissolved in boiling acetonitrile (120 cc). After 2 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with acetonitrile (2×10 cc) and dried at 40° C. under reduced pressure (0.067 kPa). 2-Amino-7-(3-fluorophenoxy)-1,8-naphthyridine (16.5 g) is produced, m.p. 165° C.

1. washAfter treatment with caustic soda and washing
2. customthe product produced (23.5 g; m.p. 161° C.)
3. dissolutionis dissolved
4. customthe crystallised solid is separated by filtration
5. washwashed with acetonitrile (2×10 cc)
6. customdried at 40° C. under reduced pressure (0.067 kPa)