Thionyl Chloride → HCID 58828522, compound

Participants

Reaction Steps

To a solution of 2-2-fluorobenzoyl)-4-methoxybenzoic acid (84) (2.05 g, 7.48 mmol) in 50 mL of dichloromethane was added thionyl chloride (2.40 mL, 14.9 mmol), followed by 3 drops of DMF. The reaction was warmed to reflux. After 1 hour, LC-MS (aliquot quenched with pyrrolidine/ACN/H2O) showed that the reaction was complete (ESI+MS for corresponding pyrrolidine amide: 328.2 [M+H]+). The reaction was concentrated in vacuo to provide an oil which was used in the next step without further purification.

Provenance & Evidence