HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-Hydroxy-4-methoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Methoxysalicylic Acid | HCID 75231 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 2-Hydroxy-4-methoxybenzoyl chloride | HCID 23118559 | 99.1% |
Reaction Steps
To a solution of 2-hydroxy-p-anisic acid (0.2 g, 1.2 mmol) in DCE (8 mL) was added thionyl chloride (0.13 mL, 1.8 mmol) and a drop of DMF. After stirring at room temperature for 4.5 h the reaction mixture was concentrated and azeotroped several times with benzene to give the acid chloride 123 as a white solid (222 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763614B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-bfaddc38c3fc471697e8ad06e946ba5b |
| Source note | uspto-grants-2010_07 |