Sodium Methoxide → HCID 58828518, compound

Participants

Reaction Steps

NaOMe (4.4M in MeOH, 1.2 mL, 5.3 mmol) was added to a solution of the ester 126 (0.69 g, 2.6 mmol) in MeOH (20 mL). The resulting mixture was heated at reflux for 2 h. It was then cooled and concentrated. 1M HCl in ether (5.5 mL) was added and the mixture filtered and concentrated to give the product 127 as a tan solid (0.87 g).

Provenance & Evidence