Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 7-Chloro-1,8-naphthyridin-2-amine | HCID 85199 | — |
| Product | HCID 20217533 | HCID 20217533 | 59.8% |
Reaction Steps
The procedure is similar to that described in Example 4, but starting with 2-amino-7-chloro-1,8-naphthyridine (17.9 g), 4-fluorophenol (44.8 g) and potassium hydroxide pellets (13.2 g; 85% purity). After 2 hours' heating at 115° C. and treatment as described above in Example 4, 2-amino-7-(4-fluorophenoxy)-1,8-naphthyridine (15.2 g) is produced, m.p. 210° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04642308 |
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| Source dataset | uspto-grants-1987_02 |
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| ORD ID | ord-3698a6ad19fb4ff2896f401eac37a368 |
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| Source note | uspto-grants-1987_02 |
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