Ethanol → HCID 20217534, compound

Participants

Reaction Conditions

Reaction Steps

The procedure is similar to that described in Example 1, but starting with 4-methoxybenzoic acid (16.4 g), N,N'-carbonyldiimidazole (17.5 g) and 2-amino-7-(2-chlorophenoxy)-1,8-naphthyridine (18.5 g). The product produced by precipitation in water (28 g; m.p. approximately 80° C.) is dissolved in boiling ethanol (800 cc). After 15 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with ethanol (2×20 cc) and dried at 40° C. under reduced pressure (0.067 kPa). N-[7-(2-chlorophenoxy)-1.8-naphthyridin-2-yl]-4-methoxybenzamide (17.8 g) is produced, m.p 190° C.

Provenance & Evidence