Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chlorophenol | HCID 7245 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 7-Chloro-1,8-naphthyridin-2-amine | HCID 85199 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 20217510 | HCID 20217510 | 76.1% |
Reaction Steps
A mixture composed of 2-amino-7-chloro-1,8-naphthyridine (17.9 g), 2-chlorophenol (51.4 g) and potassium hydroxide pellets (13.2 g; 85% purity) is heated for 4 hours at 120° C. The mixture produced is poured into 4N caustic soda (100 cc), and the precipitate formed is separated by filtration and washed with water until the pH =7. After being dried at 40°C. under reduced pressure (0.067 kPa), 2-amino-7-(2-chlorophenoxy)-1.8 naphthyridine (20.6 g) is produced, m.p. 166° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04642308 |
|---|
| Source dataset | uspto-grants-1987_02 |
|---|
| ORD ID | ord-dd40cd7b16a64bb6b42a35013b64f85b |
|---|
| Source note | uspto-grants-1987_02 |
|---|
