2-Bromophenol → HCID 20217501, compound

Participants

Reaction Conditions

Reaction Steps

The procedure is similar to that described in Example 4, but starting with 2-amino-7-chloro-1,8-naphthyridine (19.7 g), 2-bromophenol (81.5 g) and potassium hydroxide pellets (15.15 g; 85% purity). After 10 hours' heating at 120° C. and treatment under the conditions described above in Example 4, the product produced (21.5 g; m.p. 160° C.) is purified by chromatography on a column 45 mm in diameter containing silica (300 g; 0.040-0.063 mm), eluting with a mixture (95:5 by volume) of methylene chloride and methanol and collecting 100-cc fractions. After concentration to dryness of the fractions 2 to 10 at 40° C. under reduced pressure (4 kPa), 2-amino-7-(2-bromophenoxy)-1,8-naphthyridine (12.8 g) is produced, m.p. 206° C.

Provenance & Evidence