HCID 59386562, compound → HCID 59386550, compound

Participants

Reaction Steps

A mixture of (1R,2S)-ethyl 1-((2S,4R)-4-(biphenyl-4-yl)-1-((S)-2-(tert-butoxycarbonylamino)-3-(2-nitro-N-(pent-4-enyl)phenylsulfonamido)propanoyl)-4-methoxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate (95 mg, 0.109 mmol) and Grubbs II (18.46 mg, 0.022 mmol) in DCM (200 mL) was refluxed for 4 h. The reaction mixture was then concentrated in vacuo. The residue was purified by Biotage eluting with 60% EtOAc/hexane to isolate 65 mg (71%) of (2R,6S,13aS,14aR,16aS,Z)-ethyl 2-(biphenyl-4-yl)-6-(tert-butoxycarbonylamino)-2-methoxy-8-(2-nitrophenylsulfonyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[n]pyrrolo[2,1-c][1,4,8]triazacyclopentadecine-14a-carboxylate as an off-white solid.

Provenance & Evidence