HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-[4-(1-Aminoethyl)-2-fluoro-6-vinylphenyl]methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | [1-(3-Fluoro-4-methanesulfonylamino-5-vinyl phenyl)ethyl]carbamic acid tert-butyl ester | HCID 68453629 | — |
| Catalyst | Trifluoroacetic acid | HCID 6422 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[4-(1-Aminoethyl)-2-fluoro-6-vinylphenyl]methanesulfonamide | HCID 68455310 | 134.2% |
Reaction Steps
[1-(3-fluoro-4-methanesulfonylamino-5-vinyl phenyl)ethyl]carbamic acid tert-butyl ester (0.06 mmol, 20.2 mg) was dissolved in methylene chloride, 5˜6 drops of CF3COOH were added. A reaction mixture was stirred for 12 hr. A toluene was added. The reaction mixture was concentrated in vacuo to yield brownish syrup (20.8 mg, 100.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763657B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-cb073f7511d04f34b05d8bfb1cf903e4 |
| Source note | uspto-grants-2010_07 |